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Nuclear Receptors Orchestrate Detoxification Pathways

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Presentation on theme: "Nuclear Receptors Orchestrate Detoxification Pathways"— Presentation transcript:

1 Nuclear Receptors Orchestrate Detoxification Pathways
Jayanta Roy-Chowdhury, Joseph Locker, Namita Roy-Chowdhury  Developmental Cell  Volume 4, Issue 5, Pages (May 2003) DOI: /S (03)00131-X

2 Figure 1 Bilirubin Metabolism
Bilirubin uptake, intracellular storage, conjugation with glucuronic acid, and biliary excretion are mediated by SLC21A6, GSTs, UGT1A1, and ABC-C2 (MRP2), respectively. The genes for each step of this pathway are coordinately induced by activated CAR. Developmental Cell 2003 4, DOI: ( /S (03)00131-X)


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