1. Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice.
Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. A: Temporal pattern of plasma glucose concentrations maintained during the hyperinsulinemic-euglycemic clamp. B: Steady-state whole-body glucose infusion (GINF) rate during hyperinsulinemic-euglycemic clamps. C: Basal and insulin-stimulated hepatic glucose output (HGO). D: Rate of glucose disappearance (Rd). E: Insulin-stimulated muscle glucose uptake. F: Insulin-stimulated white adipose tissue glucose uptake (n = 5–6). *P < The error bars designate the SE.
James W. Perfield II et al. Diabetes 2011;60:
©2011 by American Diabetes Association