1. An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy 
Susan B. Gurley, Thomas M. Coffman 
Cell Metabolism 
Volume 12, Issue 4, Pages (October 2010)
DOI: /j.cmet
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1
Impaired Insulin Receptor Signaling in Podocytes May Promote the Development of Nephropathy through Two Mechanisms
One pathway is through effects on cytoskeletal function. In the second pathway, the absence of insulin receptor signaling may leave the podocyte susceptible to apoptosis, which can cause proteinuria, instability of the glomerular tuft, and sclerosis.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2010 Elsevier Inc. Terms and Conditions