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David M. Essayan, MD, Charity C

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1 The regulation of IL-12: Its role in infectious, autoimmune, and allergic diseases 
David M. Essayan, MD, Charity C. Fox, MD, Francesca Levi-Schaffer, PhD, Rafeul Alam, PhD, John F. McDyer, MD, Chang-You Wu, PhD, Robert A. Seder, MD  Journal of Allergy and Clinical Immunology  Volume 102, Issue 1, Pages (July 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Fresh PBMCs (2.5 × 105/250 μl) obtained from normal donors were added in triplicate to 96-well plates and stimulated with SAC (0.01% wt/vol) or PHA (3 μg/ml) in presence or absence of anti-CD40L antibody (10 μg/ml). In all experiments, cell culture supernatants were harvested 40 hours after stimulation, and IL-12 p70 protein was measured by specific ELISA (limit of detection, 7.8 pg/ml). Results are represented as mean ± SEM of six separate experiments. *Statistical significance compared with stimulated cells in media alone. Journal of Allergy and Clinical Immunology  , 11-15DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Fresh elutriated human monocytes (2.5 × 105/250 μl) from normal donors were added in triplicate to 96-well plates and stimulated with SAC (0.01% wt/vol) or cultured in media alone in presence of rhIFN-γ (10 ng/ml) and/or CD40T (2 μg/ml) or anti-IFN antibody (10 μg/ml). Supernatants were assayed at 40 hours by specific ELISA for IL-12 p70 protein. Results are represented as mean ± SEM of six experiments. *Statistical significance compared with antigen-stimulated or unstimulated cells in media alone. Journal of Allergy and Clinical Immunology  , 11-15DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

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