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Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

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Presentation on theme: "Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model."— Presentation transcript:

1 Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model.
Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model. Papilloma samples are from 12-month-old UroIICre+Fgfr3+/K644EK-RasG12D/+ mice. H&E staining shows the formation of a papilloma (A), in which BrdU immunoreactivity demonstrated cell proliferation (B). Upregulation of pERK1/2 was observed (C), as was observed in the urothelium (Fig. 1O). However, upregulation of Sprouty2 was not present in UroIICre+Fgfr3+/K644EK-RasG12D/+ mice (D). Neither pAKT(Ser473) (E) nor p-mTOR (F) was upregulated in papillomas formed in UroIICre+Fgfr3+/K644EK-RasG12D/+ mice. GFP imaging indicated Cre-recombined cells in the papilloma (G). 14× magnification was used. Scale bar: 200 μm in all panels except for G. Imran Ahmad et al. Dis. Model. Mech. 2011;4: © Published by The Company of Biologists Ltd

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