1. Plasma Levels Correlate with Clinical Benefit
Subset Group (n=73) Q1
n=18
Q2-Q3
n=36 Q4
n=19
TPC
Cmin <1110 ng/mL
Cmin ≥1110 to <2040 ng/mL
Cmin ≥2040 ng/mL OR
8 (44%)
24 (67%)
14 (74%)
Median
TTP
11.3 months
30.6 months
33.1 months
TPC=trough plasma concentrations; OR=overall response; TTP=time to progression
Adapted from: Demetri et al. ASCO-GI 2008, Study B2222.

2. Recurrence-free survival (%)
ACOSOG Z9000: Overall Survival
Recurrence-free survival (%)
Adapted from: DeMatteo et al. GI ASCO 2008.

3. Recurrence-free survival (%)
ACOSOG Z9000: Recurrence-free Survival
Recurrence-free survival (%)
Adapted from DeMatteo presentation at GI ASCO 2008.