1. Editorial II: Opioids and the neuroimmune axis
Williams J.P. , Lambert D.G.  
British Journal of Anaesthesia 
Volume 94, Issue 1, Pages 3-6 (January 2005)
DOI: /bja/aei287
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
(A) Adhesion molecules on both vascular endothelium and immune cells are up-regulated, allowing passage of immune cells through the endothelium into the surrounding inflamed tissue. Immunocytes contain endogenous opioid peptides (▾). (B) In response to sympathetic stimulation immune cells release endogenous opioid peptides into inflamed tissue (▾). (C) The released opioid peptides then bind to opioid receptors on peripheral sensory neurones ( ). (D) Opioid receptors newly synthesized in the dorsal root ganglia in response to inflammation are trafficked to the periphery where they are presented at the neuronal membrane ( ).
British Journal of Anaesthesia  , 3-6DOI: ( /bja/aei287)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions