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One- to two-hour plasma glucose concentrations over a 24-hour period in patients taking maximal doses of either glyburide (20 mg/day) or glipizide (40 mg/day) (upper curve) or bedtime NPH insulin (lower curve). One- to two-hour plasma glucose concentrations over a 24-hour period in patients taking maximal doses of either glyburide (20 mg/day) or glipizide (40 mg/day) (upper curve) or bedtime NPH insulin (lower curve). Reprinted with permission from Ref. 40. Mayer B. Davidson Clin Diabetes 2015;33: ©2015 by American Diabetes Association
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