1. NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced.
NKTfh cell–driven class switch against polysaccharide Ag is IL-21-influenced. B6 and IL-21R−/− mice were immunized s.c. with 4 μg α-GC plus 5 μg NP-Ficoll. After 21 d, sera were collected and NP-specific IgM, IgG1, IgG2b, IgG2c, and IgG3 titers determined as described in Fig. 1. Each symbol represents an individual mouse. Results are representative of two independent experiments. A two-tailed Mann–Whitney U test did not detect significant difference between the groups.
Gillian A. Lang et al. ImmunoHorizons 2019;3:88-93
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