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Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen  Carmen Rondón, MD, PhD, Natalia.

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Presentation on theme: "Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen  Carmen Rondón, MD, PhD, Natalia."— Presentation transcript:

1 Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen  Carmen Rondón, MD, PhD, Natalia Blanca-López, MD, PhD, Ana Aranda, BS, Rocío Herrera, BSN, José Luis Rodriguez-Bada, BS, Gabriela Canto, MD, PhD, Cristobalina Mayorga, PhD, María José Torres, MD, PhD, Paloma Campo, MD, Miguel Blanca, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 4, Pages e7 (April 2011) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Tolerance to grass pollen after specific SCIT.
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Rhinoconjunctivitis symptoms and use of rescue medication after treatment with specific SCIT (SCIT group) and rescue medication (control group). A, Symptom score. B, Rescue medication score. C, Rescue medication–free days. Gray bars, Baseline evaluation; black bars, 1 year after. Data are shown as medians and SEMs. P values refer to comparisons between values for the SCIT and control groups (Mann-Whitney U test). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Evolution of serum levels of sIgG to Lolium and Phleum species pollen and changes from baseline to 12 months after initiation of treatment. Serum levels of Lolium species (A and B) and Phleum species (C and D) sIgG (mean ± SEM) at baseline and 1, 3, 6, and 12 months after beginning the study are shown. Solid line, SCIT group; dotted line, control group. P values refer to comparisons between baseline values and values 12 months after initiation of treatment (Wilcoxon test). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Evolution of serum levels of sIgE to Lolium and Phleum species pollen and changes from baseline to 12 months after initiation of treatment. Serum levels of Lolium species (A and B) and Phleum species (C and D) sIgE (mean ± SEM) at baseline and 1, 3, 6, and 12 months after beginning the study are shown. Solid line, SCIT group; dotted line, control group. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Severity of LAR after specific SCIT
Severity of LAR after specific SCIT. White bars, Mild rhinitis; gray bars, moderate rhinitis; black bars, severe rhinitis. Data are shown as percentages of patients. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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