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Multigenerational cohorts in patients with asthma and allergy

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1 Multigenerational cohorts in patients with asthma and allergy
S. Hasan Arshad, DM, Wilfried Karmaus, Drmed, Hongmei Zhang, PhD, John W. Holloway, PhD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 2, Pages (February 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Three generations of the Isle of Wight birth cohort. The birth cohort participants were recruited in and have been assessed at 1, 2, 4, 10, 18, and 27 years. Data and samples were collected from the parents of the cohort in The third generation (children of the original birth cohort) have been recruited since 2010 and to date assessed at 3, 12, 24, 36, and 60 months. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Vertical and induced epigenetic transmission models. A, The vertical epigenetic transmission model proposes direct transfer of epigenetic information from parent to child in successive generations. B, The alternative model, induced epigenetic transmission, proposes that maternal disease is an essential element in the chain of epigenetic transmission of information. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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