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Developing Neutrophils Must Eat…Themselves!

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Presentation on theme: "Developing Neutrophils Must Eat…Themselves!"— Presentation transcript:

1 Developing Neutrophils Must Eat…Themselves!
Zhichao Fan, Klaus Ley  Immunity  Volume 47, Issue 3, Pages (September 2017) DOI: /j.immuni Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Autophagy Fuels Neutrophil Maturation
ATG5 or ATG7 are required for autophagy, which results in the release of free fatty acids (FFA) in neutrophil precursors. FFAs block glycolysis and enter the fatty acid oxidation pathway (FAO) to fuel oxidative phosphorylation (OXPHOS), producing the ATP needed for full neutrophil differentiation, maturation, and functionality. Immunity  , DOI: ( /j.immuni ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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