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Asparagine (Asn) deamidation in proteins is highly correlated with Asn–Gly (glycine) sequences. Asparagine (Asn) deamidation in proteins is highly correlated.

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Presentation on theme: "Asparagine (Asn) deamidation in proteins is highly correlated with Asn–Gly (glycine) sequences. Asparagine (Asn) deamidation in proteins is highly correlated."— Presentation transcript:

1 Asparagine (Asn) deamidation in proteins is highly correlated with Asn–Gly (glycine) sequences.
Asparagine (Asn) deamidation in proteins is highly correlated with Asn–Gly (glycine) sequences. In this spontaneous, non-enzymatic reaction, the amide N of the Asn side chain attacks the peptide carbonyl of the following Gly to form a transient cyclic succinimide. The latter is hydrolyzed by water to yield both D- and L-aspartate (Asp) in both α andβ linkages. A β-linked aspartate is known as isoaspartate (isoAsp). Jason Sagert, and J. Herbert Waite J Exp Biol 2009;212: ©2009 by The Company of Biologists Ltd

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