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Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis  Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko.

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Presentation on theme: "Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis  Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko."— Presentation transcript:

1 Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis 
Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko Yokoi, MD, PhD, Kazuichi Maruyama, MD, PhD, Junji Hamuro, PhD, Shigeru Kinoshita, MD, PhD, Akira Murakami, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 6, Pages e1 (December 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Lymphatic vessels and lymphoid neogenesis in the giant papillae. A, LYVE-1+ lymphatic vessels were observed in the substantia propria of giant papillae. B, CD20+ B-cell clusters (arrows) and T-cell zones (asterisk) were observed in the region corresponding to the lymphatic vessels. C, CD35+ FDCs were observed around the B-cell cluster. D, PNAd+ high endothelial venules were observed around lymphatic vessels. Original magnification ×200 (Fig 1, A and B) and ×400 (Fig 1, C and D). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 RT-PCR analysis of the ε-chain mRNA and AID mRNA expression in the giant papillae tissues. Nested RT-PCR was carried out with cDNA specimens obtained from patients with AKC/VKC (patients 1, 3, 5, 8, and 10 in Table I). The 2% agarose gel electrophoresis showed positive bands (789 bp for ε-chain mRNA and 355 bp for AID mRNA). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 IgE plasma cells and IgE+ B cells observed in the substantia propria
IgE plasma cells and IgE+ B cells observed in the substantia propria. A, CD20+ B cells were observed in the substantia propria of the giant papillae, and some of the plasma cells (arrows) were IgE+. B, CD138+ plasma cells were observed in the substantia propria of the giant papillae, and some of the plasma cells (arrowhead) were IgE+. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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