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Fig. 2. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Blocking of BMP signaling,

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Presentation on theme: "Fig. 2. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Blocking of BMP signaling,"— Presentation transcript:

1 Fig. 2. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Blocking of BMP signaling, but not of nodal signaling, inhibits autochthonous neural crest migration in zebrafish embryos. Zebrafish embryos (n=6 per group) were exposed to 10 µM of the BMP type I receptor-antagonist dorsomorphin or to 30 µM of the Alk4/5/7 nodal receptor antagonist SB  hpf. Embryos at 36 hpf were analyzed for neural crest cell migration. (A,A′) Control embryos show a normal pattern of neural crest cell migration along the dorsolateral and the dorsoventral migration pathways in upper and lateral view. (B,B′) Upon dorsomorphin treatment neural crest migration is impaired along both pathways. (C,C′) SB does not influence neural crest migration in zebrafish embryos. Arrowheads indicate melanocytes that are supposed to populate the yalk sac (red arrowheads) or the yalk extension (black arrowheads). The areas into which the melanocytes migrate by the dorso-ventral or dorso-lateral pathways are marked by red brackets. Tobias Sinnberg et al. Biology Open 2018;7:bio032656 © Published by The Company of Biologists Ltd

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