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Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations  Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós,

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Presentation on theme: "Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations  Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós,"— Presentation transcript:

1 Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations  Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós, MD, PhD, Jessica Lasky-Su, ScD, Lydiana Avila, MD, Ngoc P. Ly, MD, MPH, Catherine Liang, MPH, Barbara J. Klanderman, PhD, Benjamin A. Raby, MD, MPH, Diane R. Gold, MD, MPH, Scott T. Weiss, MD, MS, Juan C. Celedón, MD, DrPH  Journal of Allergy and Clinical Immunology  Volume 122, Issue 1, Pages e5 (July 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Pairwise (r2) LD for IL10 in Costa Rican and white (non-Hispanic) CAMP parents. ∗MAF. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Regression lines by genotype for SNPs rs (A), rs (B), and rs (C) comparing the specific IgE response to Der p 1 antigen by measured Der p 1 antigen level. Yellow, Homozygotes for the major allele; blue, heterozygotes; red, homozygotes for the minor allele. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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