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Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity  Joanne E. Sordillo, ScD, MS, Roxanne.

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Presentation on theme: "Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity  Joanne E. Sordillo, ScD, MS, Roxanne."— Presentation transcript:

1 Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity  Joanne E. Sordillo, ScD, MS, Roxanne Kelly, BS, MBA, Supinda Bunyavanich, MD, MPH, Michael McGeachie, PhD, Weiliang Qiu, PhD, Damien C. Croteau-Chonka, PhD, Manuel Soto-Quiros, MD, PhD, Lydiana Avila, MD, Juan C. Celedón, MD, DrPH, John M. Brehm, MD, MPH, Scott T. Weiss, MD, MS, Diane R. Gold, MD, MPH, Augusto A. Litonjua, MD, MPH  Journal of Allergy and Clinical Immunology  Volume 136, Issue 4, Pages e2 (October 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Effect of dust mite exposure on asthma severity by IL9 SNP genotype (CAMP study). ER, Emergency department. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Effect of dust mite exposure on asthma severity by IL9 SNP genotype (GACRS). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 A, ORs for increased severe asthma exacerbations (≥1 in the past year) in response to increased dust mite allergen exposure (≥10 μg/g) for subjects without an IL9 polymorphism (rs wild-type). B, ORs for increased severe asthma exacerbations (≥1 in the past year) in response to increased dust mite allergen exposure (≥10 μg/g) for subjects with an IL9 polymorphism (rs ). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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