1. Eric A. Osborn, and Farouc A. Jaffer JIMG 2013;6:1327-1341
Intravascular NIRF Imaging of Protease Inflammation in Experimental Atherosclerosis (A and B) Fluoroscopic and angiographic images (A, yellow dotted lines: high magnification inset of the radiopaque tip of the catheter; B, solid yellow line: intravascular catheter tip position) positioned in the rabbit aorta, proximal to the iliac bifurcation. (C) Coregistered longitudinal intravascular ultrasound (IVUS) demonstrates mild aortic plaques P1 and P2. (D) Near-infrared fluorescence (NIRF) catheter pullback aligned with images in A through C reveals NIRF protease activity at mild plaques (top) with a 1-dimensional angle-averaged NIRF plot (bottom). (E) Superimposed longitudinal IVUS and NIRF fusion images (NIRF color scale: yellow/white = strong, red/black = weak). (F and G) Longitudinal and (H and I) axial images of plaques P1 and P2. Arrowheads indicate areas of mild atherosclerotic plaque identified by IVUS. Scale bars = 10 mm.
Eric A. Osborn, and Farouc A. Jaffer JIMG 2013;6:
American College of Cardiology Foundation