1. Big Q: What role does the ribosome play in assembling proteins?
Protein Synthesis
Big Q: What role does the ribosome play in assembling proteins?

2. Engage - translate this message!
Each number represents a letter:
a=1 b=2 c=3 etc…..

3. Explain - How RNA is read by the ribosome
The genetic code contains all the base pairs of the RNA strand.
How to read the code:
1. Each letter is a base pair in the code
2. Three letters together create a “word”
3. Each word represents a codon
4. Codons represent a specific amino acid

4. The mRNA code Start codon Stop codons AUG methionine UGA, UAA, UAG
Several codons for each amino acid
mutation insurance!
Strong evidence for a single origin in evolutionary theory.
Start codon
AUG
methionine
Stop codons
UGA, UAA, UAG

6. Elaborate - Translation
Investigate how the cell interprets codons.
****Answer questions on your Quick Lab Worksheet

7. Explain - Translation
Translation - ribosomes use the sequence of codons in mRNA to assemble amino acids into a polypeptide chain.
Steps:
1. Transcription occurs(mRNA)
2. Ribosome attaches to mRNA strand(rRNA)
3. Begins when it reads AUG start codon(tRNA)
4. tRNA brings amino acids based on codons

8. Transfer RNA
The Polypeptide
Completion

9. TACGCACATTTACGTACGCGG
mRNA Translation
DNA
TACGCACATTTACGTACGCGG
AUGCGUGUAAAUGCAUGCGCC
mRNA
codon
UAC
Met
GCA
Arg
tRNA
CAU
Val
anti-codon
amino acid

10. Elaborate - Making Translation models
Using the supplies, create a model of protein synthesis.
Make sure to label the following parts:
1. mRNA
2. Ribosome
3. tRNA
4. Codon
5. Anti-codon
6. Amino Acid
7. Polypeptide
8. Base pairs

11. Evaluate - Exit Ticket Answer the following questions to be collected:
1. What are codons and anticodons?
2. Identify the following amino acids: UGG, AAG, and UGC
3. How is protein synthesis different from DNA replication?
4. What is translation?