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Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic.

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Presentation on theme: "Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic."— Presentation transcript:

1 Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy  Yuka Asai, MD, MSc, Aida Eslami, PhD, C. Dorien van Ginkel, BSc, Loubna Akhabir, PhD, Ming Wan, BSc, George Ellis, BSc, Moshe Ben-Shoshan, MD, MSc, David Martino, PhD, Manuel A. Ferreira, PhD, Katrina Allen, MD, PhD, Bruce Mazer, MD, Hans de Groot, MD, PhD, Nicolette W. de Jong, PhD, Roy N. Gerth van Wijk, MD, PhD, Anthony E.J. Dubois, MD, PhD, Rick Chin, MSc, Stephen Cheuk, MD, Joshua Hoffman, PhD, Eric Jorgensen, PhD, John S. Witte, PhD, Ronald B. Melles, MD, Xiumei Hong, MD, PhD, Xiaobin Wang, MD, MPH, ScD, Jennie Hui, PhD, Arthur W. (Bill) Musk, FRACP, Michael Hunter, PhD, Alan L. James, FRACP, Gerard H. Koppelman, MD, PhD, Andrew J. Sandford, PhD, Ann E. Clarke, MD, MSc, Denise Daley, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 3, Pages (March 2018) DOI: /j.jaci Copyright © 2017 The Authors Terms and Conditions

2 Fig 1 Quantile-quantile and Manhattan plots of related and unrelated analyses. A, Quantile-quantile plot of the expected distribution of test statistics (x-axis) versus observed P values (y-axis) for related (left) and unrelated (right) analyses. B, Manhattan plot: SNPs in 850 patients with PA and 926 hyper-control subjects for the related (upper) and unrelated (lower) analyses. The x-axis denotes the genomic location, and the y-axis denotes the association level. The solid line indicates the threshold for genome-wide significance (P ≤ 3.60 × 10−8), and the dashed line indicates the suggestive association significance threshold (P ≤ 1.49 × 10−6). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 The Authors Terms and Conditions

3 Fig 2 Quantile-quantile and Manhattan plots of related and unrelated analyses conditioned on the top HLA SNP (rs ). A, Quantile-quantile plot of the expected distribution of test statistics (x-axis) versus observed P values (y-axis) for related analysis conditioned on rs SNPs in complete linkage with rs were excluded. B, Manhattan plot: SNPs in 850 patients with PA and 926 hyper-control subjects for the related analysis conditioned on rs The x-axis denotes genomic location, and the y-axis denotes association level. The solid line indicates the threshold for genome-wide significance (P ≤ 3.60 × 10−8), and the dashed line indicates the suggestive association significance threshold (P ≤ 1.49 × 10−6). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 The Authors Terms and Conditions

4 Fig E2B Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 The Authors Terms and Conditions

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