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Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass  Sudip Ghosh, MD, Manuel Galiñanes,

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Presentation on theme: "Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass  Sudip Ghosh, MD, Manuel Galiñanes,"— Presentation transcript:

1 Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass  Sudip Ghosh, MD, Manuel Galiñanes, MD, PhD, FRCS  The Journal of Thoracic and Cardiovascular Surgery  Volume 126, Issue 1, Pages (July 2003) DOI: /S (02)

2 Figure 1A Time course of release of plasma cardiac troponin T (TnT) concentrations in patients undergoing coronary artery bypass grafting with CPB and aortic crossclamping. In each group, patients were randomly subdivided into control and preconditioning groups (n = 20/group). Data are expressed as mean ± SD (*P < .05 vs control group). Time course of release of plasma cardiac TnT concentrations in patients undergoing coronary artery bypass grafting with CPB and cold blood cardioplegia (B) and on the beating heart without CPB (C). In each group, patients were randomly subdivided into control and preconditioning groups (n = 20/group). Data are expressed as mean ± SD (*P < .05 vs control group). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (02) )

3 Figure 1A Time course of release of plasma cardiac troponin T (TnT) concentrations in patients undergoing coronary artery bypass grafting with CPB and aortic crossclamping. In each group, patients were randomly subdivided into control and preconditioning groups (n = 20/group). Data are expressed as mean ± SD (*P < .05 vs control group). Time course of release of plasma cardiac TnT concentrations in patients undergoing coronary artery bypass grafting with CPB and cold blood cardioplegia (B) and on the beating heart without CPB (C). In each group, patients were randomly subdivided into control and preconditioning groups (n = 20/group). Data are expressed as mean ± SD (*P < .05 vs control group). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (02) )

4 Figure 2 Area under the curve of the plasma release cardiac TnT in patients undergoing coronary artery bypass grafting with CPB and aortic crossclamping, CPB and cold blood cardioplegia, and on the beating heart without CPB (*P < .05 vs corresponding control group). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (02) )

5 Figure 3 CK leakage (A) during the 120-minute reoxygenation period and MTT reduction (B) at the end of the reoxygenation period after 90 minutes of normothermic global ischemia with or without simulated IP. Data are expressed as mean ± SD of 6 experiments (*P < .05 vs corresponding group without preconditioning). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (02) )

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