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Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering.

Published byLinda Clausen Modified over 5 years ago

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Presentation on theme: "Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering."— Presentation transcript:

1 Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria. (A) Percentage of CD45.1+ CBir1 T cells of the total colon LP CD4+ T cells or percentage of (B) Foxp3+ or (C) interleukin 17–positive (IL-17+), tumor necrosis factor–α–positive (TNFα+), or interferon-γ–positive (IFNγ+) CBir1 T cells among all CBir1 T cells in the colon LP after transfer on DOL16 and analysis on DOL30 in mice treated with intracolonic (ic) vehicle (PBS) or EGF on DOL10 to DOL21. (D) Percentage of CD45.1+ CBir1 T cells of the total colon LP CD4+ T cells or percentage of (E) Foxp3+ or (F) IL-17+, TNFα+, or IFNγ+ CBir1 T cells among all CBir1 T cells in the colon LP after transfer on DOL16 and analysis on DOL30 in mice treated with inhibition of EGFR activation (EGFRi) on DOL14 and DOL16, or on DOL24 and DOL26. *P < 0.05; n = 4 mice per group. Kathryn A. Knoop et al. Sci. Immunol. 2017;2:eaao1314 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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