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The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two  Carsten Flohr,

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Presentation on theme: "The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two  Carsten Flohr,"— Presentation transcript:

1 The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two  Carsten Flohr, MRCPCH, Stephan K. Weiland, MD, Gudrun Weinmayr, PhD, Bengt Björkstén, PhD, Lennart Bråbäck, PhD, Bert Brunekreef, PhD, Gisela Büchele, MPH, Michael Clausen, MD, William O.C. Cookson, PhD, Erika von Mutius, MD, David P. Strachan, MD, Hywel C. Williams, PhD  Journal of Allergy and Clinical Immunology  Volume 121, Issue 1, Pages e4 (January 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Proportion of atopy among children with flexural eczema for all study centers. Study centers are arranged in order of proportion of atopy separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Forest plot of age- and sex-adjusted ORs for atopy (exposure) and flexural eczema (outcome) for each study center (red, affluent countries; blue, nonaffluent countries). Within each group, centers are arranged in order of GNI. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 PAFs for all study centers (red, affluent countries; blue, nonaffluent countries). Study centers are arranged in order of magnitude of PAF. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 ORs for the association of atopy with flexural eczema plotted against GNI. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Flexural eczema prevalences with 95% CIs for all study centers
Flexural eczema prevalences with 95% CIs for all study centers. Study centers are arranged in order of flexural eczema prevalence, separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Atopy prevalences with 95% CIs for all study centers are arranged in order of atopy prevalence, separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fraction (%) of flexural eczema attributable to skin test reactivity (PAF) plotted against GNI.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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