1. Evaluation of E–R (AEs-DC/D) in NSCLC in the full model using (A) estimated covariate effects and (B) VPCs. For continuous variables in the covariate analysis, median reference values with their 5th and 95th percentiles (P05–P95) are shown.
Evaluation of E–R (AEs-DC/D) in NSCLC in the full model using (A) estimated covariate effects and (B) VPCs. For continuous variables in the covariate analysis, median reference values with their 5th and 95th percentiles (P05–P95) are shown. Abbreviations: AEs-DC/D, adverse events leading to discontinuation or death; Cavg1, model-predicted time-averaged steady-state concentration; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; E-R, exposure-response; HR, hazard ratio; LDH, lactate dehydrogenase; NSCLC, non-small cell lung cancer; NSQ, non-squamous; PI, prediction interval; SQ, squamous; ULN, upper limit of normal; VPC, visual predictive check.
Yan Feng et al. Clin Cancer Res 2017;23:
©2017 by American Association for Cancer Research