Presentation is loading. Please wait.

Presentation is loading. Please wait.

The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects  Neil E. Alexis, PhD, Haibo Zhou, PhD,

Published bySilvestro Patti Modified over 5 years ago

Similar presentations

Presentation on theme: "The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects  Neil E. Alexis, PhD, Haibo Zhou, PhD,"— Presentation transcript:

1 The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects  Neil E. Alexis, PhD, Haibo Zhou, PhD, John C. Lay, PhD, Bradford Harris, MD, Michelle L. Hernandez, MD, Tsui-Shan Lu, PhD, Philip A. Bromberg, MD, David Diaz-Sanchez, PhD, Robert B. Devlin, PhD, Steven R. Kleeberger, PhD, David B. Peden, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 6, Pages e5 (December 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Effect of GSTM1 genotypes on lung function response to ozone: FEV1(top) and FVC (bottom) expressed as mean (SEM) percentages of baseline values 4 and 24 hours after ozone exposure in GSTM1+ (n = 19, solid bars) and GSTM1− (n = 16, open bars) subjects. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Effect of GSTM1 genotypes on PMN and macrophage numbers in sputum in response to ozone: mean (SEM) PMNs per milligram of sputum (top) and macrophages per milligram of sputum (bottom) before (baseline) and 4 and 24 hours after ozone exposure in GSTM1+ (n = 19, solid bars) and GSTM1− (n = 16, open bars) subjects. ∗P < .05 versus baseline. +P < .05, GSTM1+ versus GSTM1−. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Effect of GSTM1 genotypes on cell function 24 hours after ozone exposure: mean (SEM) oxidative burst activity MFI (top, macrophages, GSTM1+ n = 17, GSTM1− n = 16), phagocytosis (middle, macrophages, GSTM1+ n = 19, GSTM1− n = 15), and HLA-DR expression MFI (bottom, GSTM1+ n = 9, GSTM1− n = 11) at 4 and 24 hours after ozone exposure in GSTM1+ and GSTM1− subjects. ∗P < 0.05 versus before. +P < .05 for 24-hour response in GSTM1+ versus GSTM1− subjects. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Effect ofGSTM1 genotypes on CD14 expression on airway PMNs 24 hours after ozone exposure. ∗P = .002 for the GSTM1− cohort comparing baseline with 24-hour values within this genotype. +P = .05 change from baseline values at 24 hours in GSTM1− versus GSTM1+ volunteers. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Effect ofGSTM1 genotypes on IL-1β and IL-8 levels in airway sputum recovered after exposure to ozone: GSTM1− volunteers had a significant increase in IL-1β levels 4 and 24 hours after completion of the ozone exposure protocol, as well as IL-8 levels 24 hours after ozone exposure. Nominal P values are noted in the body of the figure. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects  Neil E. Alexis, PhD, Haibo Zhou, PhD,"

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.
Nasal challenge with allergen leads to maxillary sinus inflammation

Nasal challenge with allergen leads to maxillary sinus inflammation
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S
Induced sputum proteome in healthy subjects and asthmatic patients

Induced sputum proteome in healthy subjects and asthmatic patients
Fatty acids, inflammation, and asthma

Fatty acids, inflammation, and asthma
Obstructive sleep apnea syndrome and inflammation

Obstructive sleep apnea syndrome and inflammation
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
David A. Khan, MD  Journal of Allergy and Clinical Immunology 

David A. Khan, MD  Journal of Allergy and Clinical Immunology 
Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation  Roshi Afshar, PhD, James P. Strassner, BS, Edward.

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation  Roshi Afshar, PhD, James P. Strassner, BS, Edward.
Health effects of air pollution

Health effects of air pollution
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Fatty acids, inflammation, and asthma

Fatty acids, inflammation, and asthma
Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma  Christopher Newby, PhD, Joshua Agbetile, MRCP,

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma  Christopher Newby, PhD, Joshua Agbetile, MRCP,
Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy  Michelle L. Hernandez,

Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy  Michelle L. Hernandez,
Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-γ–inducible protein 10 expression in asthmatic.

Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-γ–inducible protein 10 expression in asthmatic.

Similar presentations

Ads by Google