1. Acute hypoxia (12-hour windows).
Acute hypoxia (12-hour windows). (A–D) Hypoxic from 24–36 hours: (D) right microphthalmia. (E–H) Hypoxic from 36–48 hours, and severe malformations including (F) left microphthalmia, (G) exencephaly, bilateral microphthalmia, hypotelorism and midline defects, and (H) lack of recognizable facial characteristics. (I–L) Hypoxic from 48–60 hours, and milder anomalies including asymmetry and eye defects (J–L). (M–P) Hypoxic from 60–72 hours, and no malformations but developmental delay (O,P). Scale bars: 1 mm.
Francis Smith et al. Dis. Model. Mech. 2013;6:
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