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Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe.

Published bySusanne Zimmermann Modified over 5 years ago

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Presentation on theme: "Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe."— Presentation transcript:

1 Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study  Tmirah Haselkorn, PhD, James E. Fish, MD, Robert S. Zeiger, MD, PhD, Stanley J. Szefler, MD, Dave P. Miller, Bradley E. Chipps, MD, F. Estelle R. Simons, MD, Scott T. Weiss, MD, MS, Sally E. Wenzel, MD, Larry Borish, MD, Eugene R. Bleecker, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 5, Pages e4 (November 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Study population. Two hundred sixty-seven of 1074 patients whose pattern of asthma control was VPC-VPC-(N)WC or VPC-N(WC)-VPC were excluded. ∗Asthma control assessments at baseline, month 12, and month 24. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Risk of asthma exacerbations at the month 30 visit associated with consistently VPC asthma as defined by impairment domain of the NHLBI guidelines. Final adjusted models for hospitalization and ED visits include prior hospitalizations or ED visits, number of long-term controllers, body mass index, allergic triggers, nonallergic triggers, percent predicted forced vital capacity, race/ethnicity, and age. Final adjusted models for corticosteroid bursts include prior corticosteroid burst, chronic obstructive pulmonary disease, nonallergic triggers, percent predicted FEV1/forced vital capacity ratio, race/ethnicity, and age. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Demographic and clinical factors predictive of consistently VPC asthma as defined by the impairment domain of the NHLBI guidelines. ∗Allergic triggers considered were pollen, animal dander, dust, and mold. ∗∗Predictive factors that were statistically significantly associated with consistently poorly controlled asthma are shown. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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