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Published byRodolphe Benjamin Aubé Modified over 5 years ago
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Fumaric acid esters in combination with a 6-week course of narrow-band UVB provides for an accelerated response as compared to fumaric acid esters monotherapy in patients with moderate to severe plaque psoriasis: A randomized prospective clinical study S. Tzaneva, A. Geroldinger, H. Trattner, A. Tanew British Journal of Dermatology. DOI: /bjd.16106
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Stanislava Tzaneva, Lead author
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Introduction What’s already known?
Fumaric acid esters (FAE) - effective and safe systemic treatment option for psoriasis but slow onset of action Narrow-band UVB phototherapy - rapid improvement or clearing of psoriasis but not suitable for maintenance treatment
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Methods Randomized, assessor-blinded trial
Patients with a Psoriasis Area and Severity Index (PASI) of ≥10 and a body surface area (BSA) of ≥10 Randomization to either monotherapy with FAE (n=16) or a combination of FAE with NB UVB (n=14)
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Results Thirty patients (19 males, 11 females; median age 52 years, IQR 36;56) were analysed The mean reduction in PASI after 6 weeks was significantly greater with the combination treatment as compared to FAE monotherapy (p=0.016) Much faster improvement in DLQI in the combination group than in the FAE monotherapy group
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Results Time course of median PASI changes during treatment. Error bars represent interquartile ranges.
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Discussion What does this study add?
Combination of FAE with a short initial 6-week course of narrow-band UVB provides for an accelerated and enhanced clinical response during the early phase of treatment that is paralleled by a faster improvement of patients' quality of life.
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Conclusions Adding a 6-week course of narrow-band UVB to FAE both accelerates and augments the therapeutic response during the early phase of treatment and increases quality of life in patients with moderate-to- severe plaque psoriasis.
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Adrian Tanew, Senior author
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