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The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection  Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.

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Presentation on theme: "The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection  Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin."— Presentation transcript:

1 The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection 
Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin Markowitz, MD  Journal of Allergy and Clinical Immunology  Volume 116, Issue 2, Pages (August 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Effector sites (lamina propria) of the GI tract show pronounced CD4+ T-cell depletion in acute and early HIV-1 infection. At magnifications of 25× (A) and 80× (B), CD4+ T cells (stained red) are seen in a representative biopsy specimen from an HIV-uninfected individual. In comparison, profound CD4+ T-cell depletion is noted in low-power (C, 25×) and high-power (D, 80×) views in a specimen from a subject with acute HIV-1 infection. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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