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Fig. 1 Strategies for loading LRAs into LCNPs.

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Presentation on theme: "Fig. 1 Strategies for loading LRAs into LCNPs."— Presentation transcript:

1 Fig. 1 Strategies for loading LRAs into LCNPs.
Strategies for loading LRAs into LCNPs. Hydrophobic LRAs were physically encapsulated into the PLGA core. Chol-but, as the prodrug of butyric acid, was inserted into the lipid bilayer. LRAs with hydroxyl or amine groups were conjugated to the PLGA followed by LCNP synthesis. Prs, prostratin; PANO, panobinostat; DIC, N,N′-diisopropylcarbodiimide; DMAP, 4-(dimethylamino)pyridine; RT, room temperature; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HoBt, 1-hydroxybenzotriazole; DIPEA, N,N-diisopropylethylamine. Shijie Cao et al. Sci Adv 2019;5:eaav6322 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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