1. Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases TG secretion rates.
Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases TG secretion rates. A: Experimental protocol. B: Body weights of Nirko mice and littermate controls (n ≥ 9/group). C: Blood glucose levels of Nirko and littermate controls at baseline of the tyloxapol infusion experiment (n ≥ 9/group). D: Plasma TG levels at baseline (0) and 1 and 2 h after a tyloxapol injection in Nirko vs. littermate control mice (n ≥ 9/group). E–G: VLDL secretion rates as assessed after tyloxapol infusion experiments in Nirko, IR∆PER (n = 5/group), and IR∆WB (n ≥ 6/group) mice vs. their respective controls. All error bars are SEM. *P < 0.05 vs. controls. hrs, hours; N.S., not significant.
Thomas Scherer et al. Diabetes 2016;65:
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