1. Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline 
Joseph P. Mathew, MD, Henry M. Rinder, MD, Brian R. Smith, MD, Mark F. Newman, MD, Christine S. Rinder, MD 
The Annals of Thoracic Surgery 
Volume 81, Issue 5, Pages (May 2006)
DOI: /j.athoracsur
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Jugular-arterial (J-A) platelet activation gradient in patients with and without cognitive deficit. The gradient of P-selectin+ platelets was compared in 24 cognitive deficit (CD) patients versus 57 patients with no CD at the following time points: baseline (BASE), immediately before aortic cross-clamp release (aXCR), 5 minutes after aortic XCR (5min pXCR), and at the end of surgery (endOR). At the 5 minutes after XCR time point, patients with a CD had a significantly greater J-A platelet activation gradient (*p = 0.048).
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Jugular-arterial (JUG-ART) gradient for leukocyte-platelet conjugates in patients with and without cognitive deficit (CD). The gradient of (A) monocytes with bound platelets and (B) neutrophils (polymorphonuclear leukocytes) with bound platelets was compared in patients with and without CD at the times identified in Fig 1. The leukocyte-platelet conjugate gradient did not differ between patient groups at any time point (p > 0.05) for both (A) monocyte-platelet and (B) polymorphonuclear leukocytes-platelet. (BASE = baseline; aXCR = immediately before aortic cross-clamp release; 5min pXCR = 5 minutes after aortic XCR; endOR = at the end of surgery.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions