1. Natural Killer T Cells: An Unconventional T-Cell Subset with Diverse Effector and Regulatory Functions 
Anna Balato, Derya Unutmaz, Anthony A. Gaspari 
Journal of Investigative Dermatology 
Volume 129, Issue 7, Pages (July 2009)
DOI: /jid
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2. Figure 1
Differentiation of CD4+CD8+ T cells and activation of NKT cells. CD4+CD8+ T cells can differentiate in CD4+, CD8+, and NKT cells (that can be double negative for CD4/CD8 or may be single positive for CD4 or CD8). CD4+ T cells differentiate in Th1, Th2, Th17, and Treg. Each type of these cells is required for a specific immune response. NKT cells are stimulated by APC through CD1d–TCRαβ interaction and rapidly produce Th1 or Th2 cytokines. They also have cytotoxicity activity through TRAIL, FasL, and prf/Gr.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions