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A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease  Donald McLaren, Reisa.

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Presentation on theme: "A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease  Donald McLaren, Reisa."— Presentation transcript:

1 A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease  Donald McLaren, Reisa Sperling, Alireza Atri  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 8, Issue 4, (July 2012) DOI: /j.jalz Copyright © Terms and Conditions

2 Figure 1 Cortical surface renderings for ADAS-Cog Delayed Recall, CDR - Sum of Boxes (CDR-sb), and FCSRT Free-recall. Results for each regression were thresholded at P <0.05. Positive values (red) indicate regions where higher novel>repeated PPI was associated with better performance. Negative values (green) indicate regions where higher novel>repeated PPI was associated with worse performance. Blue circles indicate common areas between the regressions of FCSRT Free-recall and ADAS-Cog Delayed Recall. Orange circles indicate common areas between the regressions of FCSRT Free and CDR-sb. Cyan circles indicate common areas between the regressions of ADAS-Cog Delayed Recall and CDR-sb. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2012 8, DOI: ( /j.jalz ) Copyright © Terms and Conditions


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