1. The effect of TDP-43A315T expression on dendrite spine development.
The effect of TDP-43A315T expression on dendrite spine development. (A) YFP:WT and YFP:TDP-43A315T cortical neurons at 15 DIV develop extensive dendritic spines (boxed areas, enlarged in insets). (B) Quantification demonstrated a significant increase in spine density between 10 and 15 DIV in both WT and TDP-43A315T cortical neurons. There was a significant reduction in spine density in the TDP-43A315T neurons at both 10 and 15 DIV in comparison to WT controls. n=3 biological replicates. *P<0.05 (two-way ANOVA with Tukey's multiple comparisons test). Data are mean±s.e.m. Scale bar: 50 μm; 20 μm in inset.
Tongcui Jiang et al. Dis. Model. Mech. 2019;12:dmm038109
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