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Epigenetics and MicroRNAs Combine to Modulate the MDM2/p53 Axis in Myeloma
Marta Chesi, P. Leif Bergsagel Cancer Cell Volume 18, Issue 4, Pages (October 2010) DOI: /j.ccr Copyright © 2010 Elsevier Inc. Terms and Conditions
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Figure 1 Illustration of the p53–miR-192,194,215–MDM2 Auto Regulatory Loops An illustration of the p53–miR-192,194,215–MDM2 auto regulatory loops showing the central role played by the miRs in determining the balance of p53 suppressor and the MDM2 oncoprotein expression levels (adapted from Pichiorri et al., 2010). Cancer Cell , DOI: ( /j.ccr ) Copyright © 2010 Elsevier Inc. Terms and Conditions
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