1. Cancer mutations in enriched RBP motifs.
Cancer mutations in enriched RBP motifs. We provide the proportion of samples separated by tumor type (y axis) that have a mutated motif in 5SS (A), 3SS (B), CDS (C), and INTRON (D) SMRs. In each SMR type, we show the enriched motifs. For 5SS and 3SS, we indicate the consensus 5′ or 3′ splice-site sequences (5SSC/3SSC). The proportions are color coded by tumor type. We show the mutation patterns on SRSF10 motifs in 3SS (E), CDS (F), and INTRON (G) SMRs. Top, We indicate in dark red the position of the mutations and in light red the positions covered by motif. The bar plots below show the proportion of somatic mutations (y axis) that fall on each position along the motif logo. In orange indicate those somatic mutations that coincide with a germline SNP (with a different substitution pattern, as the exact matching substitutions were removed). Below we show for each position the number of motifs with each type of substitution indicated with a color code below.
Babita Singh et al. Mol Cancer Res 2018;16:
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