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Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators  Alan R Conant, PhD, Michael J Shackcloth,

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Presentation on theme: "Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators  Alan R Conant, PhD, Michael J Shackcloth,"— Presentation transcript:

1 Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators  Alan R Conant, PhD, Michael J Shackcloth, FRCS, Aung Y Oo, FRCS (CTh), Michael R Chester, MRCP, MD, Alec W.M Simpson, DPhil, Walid C Dihmis, FRCS (CTh)  The Journal of Thoracic and Cardiovascular Surgery  Volume 126, Issue 2, Pages (August 2003) DOI: /S (03)00388-X

2 Figure 1 Mean concentration (−log10 mol/L) contraction (percentage of maximal noradrenaline contraction) curve for noradrenaline in the human radial artery not treated with phenoxybenzamine in theater. Symbols represent data averaged from a group of rings (taken from 6 patients). Vertical error bars are 1 SEM values. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03)00388-X)

3 Figure 2 Representative traces showing force induced in the presence of 2 μmol/L noradrenaline in rings of human radial artery (A) not treated or (B) treated with phenoxybenzamine. Phenoxybenzamine-treated arteries were further stimulated with 60 mmol/L KCl to demonstrate functional contractility. The presence of the vasoconstrictor stimulus in the bath solution is indicated by the horizontal bar. The responses were terminated by 2 changes of media. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03)00388-X)

4 Figure 3 Representative traces showing force induced in phenoxybenzamine-treated rings of human radial artery by the application of (A) 100 nmol/L angiotensin II, (B) 100 nmol/L vasopressin, (C) 60 mmol/L KCl, and (D) 10 nmol/L endothelin-1. The presence of the agonist in the bath solution is indicated by the horizontal bar and the stimulus was removed by 2 changes of media. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03)00388-X)

5 Figure 4 Mean force generated in phenoxybenzamine-treated rings of human radial artery by the application of (A) 60 mmol/L KCl, (B) 100 nmol/L angiotensin II, (C) 100 nmol/L vasopressin, and (D) 10 nmol/L endothelin-1. Data were collected in the presence of 0.5 mg/mL (2.2 mmol/L) glyceryl trinitrate (filled bars), 0.5 mg/mL (1.3 mmol/L) papaverine (open bars), or 4.5 μg/mL (10 μmol/L) diltiazem (striped bars). Data are presented as percentage of force generated in patient-matched rings without vasodilator. Vertical error bars are 1 SEM values. *P < .05 from patient-matched control values, xP < .05 from prestimulus basal values. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03)00388-X)

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