1. Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice 
T.-L. Nguyen, Y.-S. Nam, S.-Y. Lee, H.-C. Kim, C.-G. Jang 
British Journal of Anaesthesia 
Volume 105, Issue 5, Pages (November 2010)
DOI: /bja/aeq212
Copyright © 2010 The Author(s) Terms and Conditions

2. Fig 1
Effects of capsazepine (CPZ) on nociceptive behaviours in mice. The analgesic effect was determined by calculating the AUC, obtained from a plot of analgesic percentage (ordinate) vs time in minutes (abscissa), and was expressed as a percentage of the effect observed in vehicle-treated control animals (100%). Values indicate the means (sd) of seven to eight mice.
British Journal of Anaesthesia  , DOI: ( /bja/aeq212)
Copyright © 2010 The Author(s) Terms and Conditions

3. Fig 2
Effects of CPZ on morphine (MOR)-induced analgesia in mice. The analgesic effect was determined by calculating the AUC from a plot of analgesic percentage (ordinate) vs time in minutes (abscissa), and was expressed as a percentage of the effect observed in VEH+SAL-treated control animals (100%). Values indicate the means (sd) of eight to 12 mice. *P<0.05, **P<0.01, and ***P<0.001 vs animals treated with VEH+SAL; ##P<0.01 vs animals treated with VEH+MOR5.
British Journal of Anaesthesia  , DOI: ( /bja/aeq212)
Copyright © 2010 The Author(s) Terms and Conditions

4. Fig 3
Effect of CPZ on the development of analgesic tolerance to MOR in mice. Values indicate means (sd) of eight to 15 mice. *P<0.05, ***P<0.001 vs animals treated with VEH+SAL+SAL; &&&P<0.001 vs animals treated with VEH+SAL+MOR5; ##P<0.01 vs animals treated with VEH+MOR10+MOR5.
British Journal of Anaesthesia  , DOI: ( /bja/aeq212)
Copyright © 2010 The Author(s) Terms and Conditions

5. Fig 4
Effect of repeated administration of CPZ on naloxone-induced withdrawal symptoms. (a) Escape jumping and (b) rearing in MOR-dependent mice. Values indicate means (sd) of eight to nine mice. *P<0.05 vs the VEH+SAL-treated group; #P<0.05, ##P<0.01 vs the VEH+MOR-treated group.
British Journal of Anaesthesia  , DOI: ( /bja/aeq212)
Copyright © 2010 The Author(s) Terms and Conditions