1. The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases 
Saleh Al-Muhsen, MD, Jean-Laurent Casanova, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 122, Issue 6, Pages (December 2008)
DOI: /j.jaci
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Geographical origin of the kindreds with genetic defects of MSMD. Patients were diagnosed from 44 countries on 6 different continents: Africa (Algeria, Cameroon, Morocco, Tunisia); North America (Canada and United States); South America (Argentina, Brazil, Canada, Chile, French West Indies, Mexico, Venezuela); Asia (China, India, Indonesia, Iran, Israel, Japan, Lebanon, Malaysia, Pakistan, Qatar, Saudi Arabia, Sri Lanka, Taiwan, Turkey); Europe (Belgium, Bosnia, Cyprus, France, Germany, Greece, Italy, Malta, The Netherlands, Norway, Portugal, Poland, Slovakia, Spain, Sweden, United Kingdom, Ukraine); and Oceania (Australia).
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
MSMD-causing genes in the IL-12/23-IFN-γ pathway. Schematic representation of host immune defense against mycobacterial infection. Proteins for which mutations in the corresponding genes have been identified and associated with susceptibility to mycobacterial diseases are shown in red. Allelic heterogeneity of the 6 genes results in the distinct 13 genetic disorders. The IL12-23/IFN-γ is crucial for protective immunity to mycobacterial infection in human beings. TYK-2, Tyrosine kinase 2; JAK2, Janus kinase 2.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions