1. Fig. 1. Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway. OR, odds ratio; Ref, reference. (A) HLA DQ, Major histocompatibility complex, class II, DQ; HLA-DPB1, Major histocompatibility complex, class II, DP beta 1; IL4, INTERLEUKIN 4; IL 13, INTERLEUKIN 13; TBET, T-BOX EXPRESSED IN T CELLS; IL-10, Interleukin 10; TGF-beta 1, transforming growth factor, beta 1. (B) MS4A2, MEMBRANE-SPANNING 4-DOMAINS, SUBFAMILY A, MEMBER 7; FCER1γ, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; FCER1α, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide. (C) LTC4S, Leukotriene C4 syntrhase; CACNG6, Calcium channel, voltage-dependent gamma-6 subunit; ALOX5, Arachidonate 5-lipoxygenase; NAT2, N-Acytyltransferase 2; CysLTR1, Cysteinyl leukotriene receptor 1; CysLTR2, Cysteinyl leukotriene receptor 2. (D) TLR3, TOLL-LIKE RECEPTOR 3. (E) NLRP3, NLR FAMILY, PYRIN DOMAIN-CONTAINING 3; PPARG, Peroxisome proliferator-activated receptor-gamma; ACE, Angiotensin 1-converting enzyme; ADAM33, A distegrin and metalloproteinase domain 33; FSIP1, Fibrous sheath interacting protein 1; EMID2, Emilin/multimerin domain-containing protein 2; SMOC2, Sparc-related modular calcium-binding protein 2; SLC6A12, Solute carrier family 6 (neurotransmitter transporter, betaine/gaba), member 12; SLC22A2, Solute carreier familyY 22 (organic cation transporter), member 2; KIF3A, Kinesin family member 3A. (F) ADORA1, adenosine A1 receptor; ADORA2A, adenosine A2a receptor; GPR44, G protein-coupled receptor 44; PTGER2, Prostaglandin E Receptor 2; PTGER3, Prostaglandin E Receptor 3; PTGER4, Prostaglandin E Receptor 4; PTGIR, Prostaglandin I2 receptor; TBXAS1, Thromboxane A synthase 1; TBXA2R, Thromboxane A2 receptor; RGS7BP, Regulator of G protein signaling 7-binding protein.
Fig. 1. Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway. OR, odds ratio; Ref, reference. (A) HLA DQ, Major histocompatibility complex, class II, DQ; HLA-DPB1, Major histocompatibility complex, class II, DP beta 1; IL4, INTERLEUKIN 4; IL 13, INTERLEUKIN 13; TBET, T-BOX EXPRESSED IN T CELLS; IL-10, Interleukin 10; TGF-beta 1, transforming growth factor, beta 1. (B) MS4A2, MEMBRANE-SPANNING 4-DOMAINS, . . .
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