1. A new formulation for appetite control.
A new formulation for appetite control. A proposed tonic signal for the drive to eat that reflects the body’s demand for energy arises (mainly) from FFM and RMR. In turn, this drive is under tonic inhibition from leptin, whose action reflects the amount of stored energy reserves in the body. As the amount of adipose tissue increases, leptin insensitivity occurs and this tonic inhibition is reduced. The drive to eat is periodically interrupted and suppressed by episodic signals in the form of peptides that are released from the GI tract in response to food consumption. The resulting pattern of eating is a consequence of the interactions between tonic and episodic physiological signals. The figure also illustrates the postulated effect of exercise on appetite control. Prolonged exercise displays a dual-process action by stimulating hunger (an effect that is highly variable between individuals) but also by increasing post-prandial satiety signalling (King et al., 2009) through an effect on GI peptides (Martins et al., 2010). See text for further description.
John E. Blundell et al. Dis. Model. Mech. 2012;5:
© Published by The Company of Biologists Ltd