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Fig. 5. (A) The effect of PKA and PI3K inhibitors on VEGF production in NPDFs. KT5720 and LY294002 significantly decreased VEGF production. (B) The effect.

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Presentation on theme: "Fig. 5. (A) The effect of PKA and PI3K inhibitors on VEGF production in NPDFs. KT5720 and LY294002 significantly decreased VEGF production. (B) The effect."— Presentation transcript:

1 Fig. 5. (A) The effect of PKA and PI3K inhibitors on VEGF production in NPDFs. KT5720 and LY significantly decreased VEGF production. (B) The effect of PKA and PI3K inhibitors on cAMP release. PGE2 with KT5720 elicited a decrease in cAMP release, whereas PGE2 with LY did not. The means±SE of data from six experiments are shown. *P<0.05 vs. control and †P<0.05 vs. PGE2. VEGF, vascular endothelial growth factor; cAMP, cyclic adenosine monophosphate; PGE2, prostaglandin E2; PKA, protein kinase A; PI3K, phosphatidylinositol 3-kinase; KT5720, PKA inhibitor; LY294002, PI3K inhibitor; Forskolin, cAMP activator; VEGF, vascular endothelial growth factor; NPDFs, nasal polyp-derived fibroblasts; SE, standard error. Fig. 5. (A) The effect of PKA and PI3K inhibitors on VEGF production in NPDFs. KT5720 and LY significantly decreased VEGF production. (B) The effect of PKA and PI3K inhibitors on cAMP release. PGE2 with KT5720 elicited a decrease in cAMP release, whereas PGE2 with LY did not. The means±SE of data from six experiments are shown. *P<0.05 vs. control . . . Allergy Asthma Immunol Res Jul;5(4):

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