1. Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity in mouse brain.
Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity in mouse brain. Immunohistochemical detection of phospho–Thr231-tau (AT180) in control mouse brain showed extensive neuronal labeling in cerebral cortical (A) and in hippocampal neurons (B). Identically processed, stained, and imaged sections from streptozotocin-treated mice showed a marked increase in phospho–Thr231-tau (AT180) immunoreactivity in both of these regions. Each group consisted of four animals, and the illustrated immunohistochemical findings were consistent among all group members.
Buffie J. Clodfelder-Miller et al. Diabetes 2006;55:
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