1. Heme Oxygenase 1: Does It Have a Role in Renal Cytoprotection?
Aisling E. Courtney, MPhil, MRCP, A. Peter Maxwell, PhD, FRCP 
American Journal of Kidney Diseases 
Volume 51, Issue 4, Pages (April 2008)
DOI: /j.ajkd
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

2. Figure 1
Heme oxygenase–catalyzed degradation of heme. Abbreviations: NADPH, reduced form of NADP; NADP, nicotinamide adenine dinucleotide phosphate; Fe, iron; CO, carbon monoxide.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

3. Figure 2
Schematic representation of human heme oxygenase-1 gene. The regulatory sequence shown is limited to components of the proximal promoter region. Abbreviations: HSE, heat shock element; (GT)n, polymorphic GT repeat sequence; NF-κB, nuclear factor-κB; AP-2, activator protein-2; StRE, stress-responsive element; CdRE, cadmium-response element. The TATA box at the transcription start site is also shown. A more complete illustration of the known transcriptions factors influencing HO-1 expression is available in Sikorski et al1 and Alam and Cook.8
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

4. Figure 3
Induction of heme oxygenase 1 (HO-1) gene expression by multiple mediators of renal injury leading to potential renal cytoprotection. Abbreviation: NF-κB, nuclear factor-κB.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions