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Loratadine reduces allergen-induced mucosal output of α2-macroglobulin and tryptase in allergic rhinitis  Lennart Greiff, MD, PhDa, Carl G.A. Persson,

Published byJerome Jenkins Modified over 5 years ago

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Presentation on theme: "Loratadine reduces allergen-induced mucosal output of α2-macroglobulin and tryptase in allergic rhinitis  Lennart Greiff, MD, PhDa, Carl G.A. Persson,"— Presentation transcript:

1 Loratadine reduces allergen-induced mucosal output of α2-macroglobulin and tryptase in allergic rhinitis  Lennart Greiff, MD, PhDa, Carl G.A. Persson, PhDb, Christer Svensson, MD, PhDa, Ingrid Enander, PhDc, Morgan Andersson, MD PhDa  Journal of Allergy and Clinical Immunology  Volume 96, Issue 1, Pages (July 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 FIG. 1 Nasal peak expiratory flow rates in response to diluent and allergen challenges (102, 103, and 104 SQ-U) after placebo and loratadine treatment, respectively. Loratadine increased the nasal peak expiratory flow rates as compared with placebo. *p < PEF, Peak expiratory flow. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 FIG. 2 Lavage fluid levels of tryptase in response to diluent and allergen challenges (102, 103, and 104 SQ-U) after placebo and loratadine treatment, respectively. Loratadine reduced the allergen-induced mucosal output of tryptase compared with placebo, suggesting reduced mast cell degranulation. *p < 0.05; **p < 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 FIG. 3 Lavage fluid levels of α2-macroglobulin in response to diluent and allergen challenges (102, 103, and 104 SQ-U) after placebo and loratadine treatment, respectively. Loratadine reduced the allergen-induced mucosal output of α2-macroglobulin compared with placebo, indicating a decreased plasma exudation response. *p < 0.05; **p < 0.01. Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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