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Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. Loss of LAR phosphatase activity is associated with decreased.

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Presentation on theme: "Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. Loss of LAR phosphatase activity is associated with decreased."— Presentation transcript:

1 Loss of LAR phosphatase activity is associated with decreased adhesion complex formation.
Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. (A–D) WT and LARΔP MEFs were serum-starved overnight before being cultured in the presence or absence of 20 ng ml−1 PDGF-BB for 14 min. Fixed and permeabilised cells were stained using an antibody against phosphorylated paxillin Tyr118 to visualise adhesion complexes. Nuclei were visualised using DAPI. Scale bar: 20 μm. (E) The cell area occupied by adhesion complexes was calculated using ImageJ and expressed as a percentage of the total cell area. Data presented in E are mean±s.e.m. from three separate experiments with four or five representative cells analysed per experiment. Statistical significance was calculated by first normalising the data by arcsine transformation, followed by a one-way ANOVA with post hoc Tukey's test (**P<0.01, ***P<0.001). Adil R. Sarhan et al. J Cell Sci 2016;129: © Published by The Company of Biologists Ltd

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