1. Cardiovascular effects of inhaled nitric oxide in a canine model of cardiomyopathy 
Evan Loh, MD, Edward B. Lankford, MD, PhD, David J. Polidori, MD, Elana B. Doering-Lubit, MD, PhD, C.William Hanson, MD, Michael A. Acker, MD 
The Annals of Thoracic Surgery 
Volume 67, Issue 5, Pages (May 1999)
DOI: /S (99)

2. Fig 1
LV pressure volume loops and regressed ESPVR from 1 animal before rapid ventricular pacing at baseline (left) and after rapid ventricular pacing with heart failure before inhalation of NO (right). Heart failure in these animals was accompanied by a rightward shift in LV volume relations and a decrease in the ESPVR slope (Ees).
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3. Fig 2
LV pressure volume loops and the ESPVR in a single animal with heart failure after rapid ventricular pacing with NO (80 ppm [solid lines]) and without NO (dashed lines). No significant shift of the ESPVR by NO was observed. LV loops used to generate ESPVR before NO are those shown in Figure 1 as “Pre-NO ESPVR.”
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4. Fig 3
Composite ESPVR fit using the regressed lines from each animal and under each condition. The equations were used to predict volumes from pressures, and the volumes used to compute mean and standard errors at each end-systolic pressure. There is a near-parallel shift of the ESPVR with NO. The left of the figure demonstrates the shift of the ESPVR by NO, and the standard error of the volume. At no pressure was there a significant shift of the ESPVR.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5. Fig 4
LVEDPVR after RVP without and with inhaled NO (n = 7). EDPVR as predicted by curve fit relations of diastolic data. The upper (dashed) curve is the relation from data before NO administration, and lower (solid) curve from data with NO at 80 ppm. The error bars are the standard deviation of the pressure difference computed from each animal’s data. At no volume was the decrease of LVEDPVR significant.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )