1. Abnormalities that are combined with or are indicators for life-threatening defects (Sc4).
Abnormalities that are combined with or are indicators for life-threatening defects (Sc4). (A) Coronally sectioned, volume rendered, 3D model of a wild-type (+/+) embryo. Note the position of the stomach (sto), highlighted in C. Note the positions of the ventral and dorsal pancreas (pa). (B) Mks1−/− embryo with a right-sided stomach, highlighted in D. Note that there is only right-sided pancreas tissue. (E) Symmetric left- and right-sided (arrowheads) aortic arch, forming a vascular ring around the esophagus (Msk1−/−). Note the abnormal position of the atrium (at). (F) Hypoplasia of the left lobe (lty) of the thyroid gland in a Ltbp1−/− embryo. (G) Retro-esophageal left subclavian artery (al) in a Csrp2bp−/− embryo. Note the inverse position of the descending aorta (da). (H) Retro-esophageal right subclavian artery in a Mbtd1−/− embryo. e, esophagus; ki, kidney; li, liver; rty, right thyroid lobe; sa, subclavian artery; t, trachea; tg, trigeminal ganglion; th, thymus; ul, upper limb; v, ventricle. Scale bars: 1 mm.
Wolfgang J. Weninger et al. Dis. Model. Mech. 2014;7:
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