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The Restenosis “Antitheory”

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1 The Restenosis “Antitheory”
Eric J. Topol, M.D.  Mayo Clinic Proceedings  Volume 68, Issue 1, Pages (January 1993) DOI: /S (12) Copyright © 1993 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Fig. 1 Diagram of classic theory and “antitheory” of restenosis. In the classic theory, predominant wave front originates from medial smooth muscle cell, which changes phenotype and undergoes migration and proliferation. The antitheory emphasizes the role of thrombus as a “bioabsorbable matrix” for cell colonization and intimal proliferation. Final result of both processes is similar. Mayo Clinic Proceedings  , 88-90DOI: ( /S (12) ) Copyright © 1993 Mayo Foundation for Medical Education and Research Terms and Conditions


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